People who have narcolepsy or OSA usually take PROVIGIL 1 time each day in the morning. are allergic or developed a rash to modafinil or armodafinil (NUVIGIL® ) or the ingredients in PROVIGIL. See the end of the Medication Guide for a complete set of ingredients in PROVIGIL. If you have a severe rash with PROVIGIL, stopping the medicine might not keep carefully the rash from becoming life-threatening or triggering someone to be permanently disabled or disfigured.
Other CYP activities didn't seem to be affected by modafinil. The pharmacokinetics and metabolism of modafinil were examined in patients with cirrhosis of the liver . Three patients had stage B or B+ cirrhosis and 6 patients had stage C or C+ cirrhosis (per the Child-Pugh score criteria). In these patients, the oral clearance of modafinil was decreased by about 60% and the steady state concentration was doubled in comparison to normal patients .
Patients treated with PROVIGIL showed a statistically significant prolongation in the time to sleep onset compared to placebo-treated patients, as measured by the nighttime MSLT at final visit . A statistically significant greater number of patients treated with PROVIGIL showed improvement in overall clinical condition as rated by the CGI-C scale at final visit . Patients treated with PROVIGIL showed a statistically significant improvement in the ability to remain awake compared to placebo-treated patients as measured by the MWT at final visit . The 200 mg and 400 mg doses of PROVIGIL produced statistically significant ramifications of similar magnitude on the MWT, and also on the CGI-C.Full Article